Author

Janakiram Reddy Vangala

Virginia Commonwealth UniversityORCID 0000-0001-8494-8461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Senthil K. RadhakrishnaniD· 2 shared Adolfo Gabriele MauroiD· 1 shared Ahmed M. ElshazlyiD· 1 shared Fadi N. SalloumiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersPharmacology & Toxicology

Senthil K. RadhakrishnanORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJun 24, 2026

Tumor-selective Mcl1 degradation by AUTAC uncouples antitumor efficacy from cardiotoxicity

Ahmed M. Elshazly, Janakiram Reddy Vangala, Adolfo Gabriele Mauro…·Senthil K. Radhakrishnan

This paper shows that AUTAC selectively degrades Mcl1 in tumors without affecting the heart, improving antitumor efficacy while avoiding cardiotoxicity.

1 citation

mouseexperimental assay

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Molecular BiologyJournal of Biological ChemistryPeer-reviewedDec 17, 2018

Proteotoxic stress-induced Nrf1 transcriptional program requires a functional TIP60 complex

Janakiram Reddy Vangala, Senthil K. Radhakrishnan

The paper identifies RUVBL1 and TIP60 as essential regulators of Nrf1-mediated transcription of proteasome genes, showing their role in cellular response to proteotoxic stress.

30 citations

humanbulk RNA-seq

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