Tumor-selective Mcl1 degradation by AUTAC uncouples antitumor efficacy from cardiotoxicity
Ahmed M. Elshazly, Janakiram Reddy Vangala, Adolfo Gabriele Mauro…·Senthil K. Radhakrishnan
This paper shows that AUTAC selectively degrades Mcl1 in tumors without affecting the heart, improving antitumor efficacy while avoiding cardiotoxicity.