Senthil K. Radhakrishnan

Tumor-selective Mcl1 degradation by AUTAC uncouples antitumor efficacy from cardiotoxicity

This paper shows that AUTAC selectively degrades Mcl1 in tumors without affecting the heart, improving antitumor efficacy while avoiding cardiotoxicity.

Proteasome Inhibition Enhances Lysosome-mediated Targeted Protein Degradation

This paper shows that combining proteasome inhibitors with lysosome-targeted degradation enhances cancer cell death by exploiting an adaptive autophagy response.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.

Proteotoxic stress-induced Nrf1 transcriptional program requires a functional TIP60 complex

The paper identifies RUVBL1 and TIP60 as essential regulators of Nrf1-mediated transcription of proteasome genes, showing their role in cellular response to proteotoxic stress.