Author

Alireza Lorzadeh

University of Southern CaliforniaORCID 0000-0001-8500-7487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:ChIP-seq· 3 Assay:DNA methylation· 3 Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:benchmark study· 1

Frequent Co-Authors

George YeiD· 3 shared Sweta Sharma· 3 shared Unmesh JadhaviD· 3 shared Abdulrahman SalhabiD· 1 shared Adriana Redensek· 1 shared Akshita Puri· 1 shared Alec R. ChapmaniD· 1 shared Alex P. ReynoldsiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersDevelopmental Biology

George YeORCID

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4 papers

Recent·Most cited

Developmental BiologybioRxivPreprintOct 9, 2026

CDX2 Drives Divergent Regional Programs During Intestinal Development and Redeploys Them During Regeneration

Alireza Lorzadeh, George Ye, Maile Romero-Wolf…·Unmesh Jadhav

This study shows CDX2 organizes enhancer networks during intestinal development and regeneration, reusing fetal and adult programs to restore regional identity.

DOI 10.64898/2026.09.29.755502

mousebulk RNA-seq

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GenomicsbioRxivPreprintJun 26, 2026

EpiATLAS - a reference for human epigenomic research

Quirin Manz, Misha Bilenky, Dennis Hecker…·Samuel A. J. R. Aparicio

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

2 citations

humanChIP-seq

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Cancer BiologybioRxivPreprintJun 8, 2026

Epigenetic Gatekeeping of Wnt-Responsive Enhancers Restricts Intestinal Stem Cell Transformation

Alireza Lorzadeh, Sweta Sharma, George Ye…·Unmesh Jadhav

This study identifies H3K27me3 as an epigenetic barrier that restricts intestinal stem cell transformation by maintaining enhancer repression and preventing fetal gene reactivation in colorectal cancer.

DOI 10.64898/2026.01.31.702974

mousehuman

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Molecular BiologybioRxivPreprintFeb 11, 2024

DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes

Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhav

The paper shows how Cdx2 binds different DNA motifs in developing and adult cells, leading to distinct gene activation patterns through methylation-dependent and -independent mechanisms.

1 citation

mouseDNA methylation

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