Author

Sweta Sharma

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Alireza LorzadehiD· 3 shared George YeiD· 3 shared Unmesh JadhaviD· 3 shared Eric SancheziD· 1 shared Maile Romero-WolfiD· 1 shared Maria Lerica Quiloan· 1 shared Ramesh A. ShivdasaniiD· 1 shared Sabrina Rabaya· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 27 mutual co-author links

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3 shared papersDevelopmental Biology

Alireza LorzadehORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CDX2 Drives Divergent Regional Programs During Intestinal Development and Redeploys Them During Regeneration

Alireza Lorzadeh, George Ye, Maile Romero-Wolf, Maria Lerica Quiloan, Sweta Sharma, Eric Sanchez, Unmesh Jadhav

This study shows CDX2 organizes enhancer networks during intestinal development and regeneration, reusing fetal and adult programs to restore regional identity.

bioRxiv · Oct 9, 2026 · PreprintDevelopmental Biology

Epigenetic Gatekeeping of Wnt-Responsive Enhancers Restricts Intestinal Stem Cell Transformation

Alireza Lorzadeh, Sweta Sharma, George Ye, Sabrina Rabaya, Yun Jee Kang, Ramesh A. Shivdasani, Unmesh Jadhav

This study identifies H3K27me3 as an epigenetic barrier that restricts intestinal stem cell transformation by maintaining enhancer repression and preventing fetal gene reactivation in colorectal cancer.

bioRxiv · Jun 8, 2026 · PreprintCancer Biology

DNA methylation-dependent and -independent binding of CDX2 directs activation of distinct developmental and homeostatic genes

Alireza Lorzadeh, George Ye, Sweta Sharma, Unmesh Jadhav

The paper shows how Cdx2 binds different DNA motifs in developing and adult cells, leading to distinct gene activation patterns through methylation-dependent and -independent mechanisms.

bioRxiv · Feb 11, 2024 · PreprintMolecular Biology