Rakesh K. Sindhi

The paper analyzes spatial molecular patterns in liver disease and transplant outcomes using single-cell RNA sequencing data from multiple conditions and post-transplant biopsies.

The paper identifies molecular and spatial features of early liver transplant rejection, including primed T-cells, immune synapse activation, and novel drug targets like proteasomal and HSP90 inhibitors.

The paper identifies differentially methylated regions in children after liver transplant that are associated with rejection, highlighting immune-related pathways and potential therapeutic targets.