Fiona Francis

The paper investigates Eml1 mutations in mice, finding altered organelle distribution and translation defects in radial glia cells, contributing to subcortical heterotopia.

This study shows that heterotopic neurons in EmlJ knockout mice retain functional properties similar to neocortical neurons despite their abnormal location.

This study uses LIS1-lissencephaly patient organoids to identify severity-dependent phenotypes and molecular mechanisms, and demonstrates that mTOR inhibitors can rescue disease-related changes.

The paper investigates the role of Lis1 in generating basal radial glia-like cells in the mouse, showing that Lis1 depletion prevents their formation and disrupts brain development.