Denis Jabaudon

This study creates a single-nucleus RNA-seq atlas of Astyanax mexicanus embryogenesis, revealing tissue-specific transcriptional tempo shifts and developmental microevolution mechanisms.

This study shows that post-mitotic cortical neurons retain birthdate-dependent differentiation potential, with early-born neurons maintaining a broader repertoire than late-born neurons.

This study compares prenatal cortical development in two rodents, showing that major developmental milestones occur prenatally in Acomys, challenging the view that postnatal experience is essential for early brain maturation.

The paper identifies JUNB as a gene driving species-specific cortical features by comparing gene expression in mouse, human, and human cortical organoids.

The paper investigates how environmental factors influence neocortical neuron fate and diversity through in vivo and in vitro experiments, showing population-specific responses and the importance of extracellular context.

The paper shows that first-order thalamic neurons develop from higher-order neurons with peripheral input driving excitatory neuron maturation.

This study shows that heterotopic neurons in EmlJ knockout mice retain functional properties similar to neocortical neurons despite their abnormal location.

The paper identifies two distinct astrocyte lineages in the mouse neocortex using single-cell RNA sequencing and TrackerSeq, revealing their developmental origins and regulatory mechanisms.

The paper identifies regional differences in progenitor dynamics during brain development, showing sustained neurogenesis in the forebrain and transient neurogenesis in the hindbrain, driven by differences in cell cycle length and progenitor consumption.

The paper identifies developmental molecular programs that control the emergence and area-specific distribution of two subtypes of cortical motor projection neurons.

The paper investigates how extracellular vesicles (EVs) mediate developmental cues during brain development and disease, finding altered EV composition and function in neurodevelopmental disorders.

The paper uses single-cell RNA-sequencing to identify quiescent neural stem cells in the dorsal V-SVZ and shows that TGFbeta/BMP signalling drives their quiescence and blocks glutamatergic neurogenesis.

The paper shows that extracellular environment factors, specifically extracellular vesicles, influence neuronal differentiation and migration by altering transcriptomic profiles in neural progenitor cells.

The paper shows that inhibiting TRPV4 rescues social and circuit deficits in Shank3 mutant mice induced by inflammation.

This study shows that loss of Lhx2 in cortical progenitors leads to premature thalamocortical innervation due to altered subplate neuron development.

The paper shows that PlexinA4-Semaphorin3A signaling between deep and superficial cortical interneurons regulates their laminar positioning in the developing neocortex.

The paper identifies CSF-delivered Semaphorin complexes that regulate apical progenitor dynamics in the developing neocortex through distinct signaling pathways.

This study identifies that the transcriptional identities of intracortically-projecting neurons primarily reflect their input-output connectivities rather than their birth dates or laminar positions.

This study shows that apical progenitors remain multipotent throughout cortical neurogenesis, reverting their temporal identity and generating neurons from earlier developmental stages.

This paper describes a protocol for in vivo pulse-labeling of newborn cells in the central nervous system using carboxyfluorescein esters, enabling tracking and isolation for downstream analysis.

The paper traces transcriptional trajectories of progenitors and neurons during mouse neocortex development, showing how molecular states from progenitors shape neuronal diversity.

The paper develops ConnectID, a method linking connectome and transcriptome in single neurons, identifying transcriptional modules associated with axonal projections to specific cortical and subcortical targets.

The paper uses FlashTag to study neuronal subtype production during corticogenesis, finding bimodal diversity in early and later stages.