David A. Wolk

Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration

The paper identifies potential diagnostic biomarkers for frontotemporal lobar degeneration subtypes using cerebrospinal fluid proteomics.

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

The precision of hippocampal representations predicts incremental value-learning across the adult lifespan

This study shows that hippocampal representation precision predicts value-learning accuracy across age groups, with reduced hippocampal-mPFC connectivity linked to poorer performance in older adults.

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

Automatic segmentation of medial temporal lobe subregions in multi-scanner, multi-modality MRI of variable quality

This paper develops a multi-modality MRI segmentation model to improve robustness of medial temporal lobe subregion segmentation in poor-quality images.

Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases

The paper develops a segmentation protocol for anterior medial temporal lobe regions and integrates it into an automated approach to improve imaging biomarkers for neurodegenerative diseases.

Neural correlates of age-related changes in social decisions from episodic memory

The paper investigates age-related changes in social decision-making by analyzing neural correlates of trust decisions based on episodic memory in older and younger adults.

Cytoarchitectonic gradients of laminar degeneration in behavioral variant frontotemporal dementia

This study examines laminar neurodegeneration patterns in bvFTD-tau and bvFTD-TDP, finding progressive SMI32-ir loss along a frontal cortical gradient in tau pathology.

α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies

The paper identifies plasma α-synuclein conformations that distinguish Parkinson's disease from dementia with Lewy bodies and predict cognitive decline in PD.

Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

Novel genomic loci and pathways influence patterns of structural covariance in the human brain

The paper identifies 617 novel genomic loci and pathways associated with structural covariance patterns in the human brain using a stochastic multivariate factorization method.

Genome-wide association study and functional validation implicates JADE1 in tauopathy

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

This study investigates how TMEM106B and C9orf72 genetic variants influence TDP-43 pathology in ALS and FTLD-TDP, finding TMEM106B modifies TDP-43 aggregation severity.

Joint ex vivo MRI and histology detect iron-rich cortical gliosis in Tau and TDP-43 proteinopathies

This study uses joint ex vivo MRI and histology to identify distinct iron-rich gliosis patterns in FTLD-Tau and FTLD-TDP, distinguishing them from other neurodegenerative conditions.

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

Neural and behavioral correlates of episodic memory are associated with temporal discounting in older adults

The paper examines the link between episodic memory and temporal discounting in older adults, finding that better memory correlates with less discounting of delayed rewards.

ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration

This paper evaluates the ATN framework's accuracy in diagnosing Alzheimer's disease subtypes and frontotemporal lobar degeneration using cerebrospinal fluid biomarkers, finding that non-amnestic Alzheimer's patients have lower tau levels and the framework is less sensitive to frontotemporal lobar degeneration.

Links between autobiographical memory richness and temporal discounting in older adults

This study examines how autobiographical memory richness relates to temporal discounting in older adults and finds that specific memory details influence decision-making.

Disconnectome Associated with Progressive Ischemic Periventricular White Matter Lesions

The paper uses a virtual lesion approach to simulate the disconnectome caused by progressive ischemic periventricular white matter lesions and validates it using DTI and fMRI data from elderly subjects.

Harmonization of large multi-site imaging datasets: Application to 10,232 MRIs for the analysis of imaging patterns of structural brain change throughout the lifespan

The paper harmonizes 10,232 structural brain MRIs from 18 studies to create a normative reference of brain development and aging across 3 to 96 years.

Preserved global cerebral blood flow accounts for youthful processing speed in older adults

The paper investigates the relationship between global cerebral blood flow and processing speed in older adults, finding that preserved global CBF correlates with youthful processing speed.