Author

Karthik Prabhakaran

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 7 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 8 Organism:human· 7 Approach:statistical model· 5 Research Focus:spatial domain detection· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

David A. WolkiD· 6 shared Matthew Dylan TisdalliD· 6 shared Paul A. YushkevichiD· 6 shared Sandhitsu R. DasiD· 6 shared Daniel T. OhmiD· 5 shared Edward B. LeeiD· 5 shared John A. DetreiD· 5 shared Ranjit Ittyerah· 5 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

David A. WolkORCID

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Author profile →

8 papers

Recent·Most cited

Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies

Pulkit Khandelwal, Michael Tran Duong, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Sydney Lim, Amanda E Denning, Eunice P. Chung, Christopher A. Olm, Hamsanandini Radhakrishnan, Ranjit Ittyerah, Karthik Prabhakaran, Gabor Mizsei, Theresa Schuck, Sheina Emrani, , Paul A. Yushkevich

The paper examines subcortical and limbic volume associations with cortical thinning and neurodegenerative pathologies in postmortem brain MRI data from multiple disease groups.

Alzheimer s & Dementia · Jul 1, 2026Peer-reviewedNeuroscience

Characterization of hippocampal subfields using histology-based annotated postmortem MRI: Lessons for in vivo segmentation II

HL Tucker, Bradley G. Karat, AT De Ruiter, Dana M. Parker, Sydney Lim, AE Denning, Ranjit Ittyerah, Lisa M Levorse, Winifred Trotman, Alejandra Bahena, Eunice P. Chung, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Long Xie, , LEM Wisse

The paper characterizes hippocampal subfield border variability using postmortem MRI and histology, finding consistent subfield appearance/disappearance orders and no clear diagnosis-related differences.

bioRxiv · Nov 21, 2025 · PreprintNeuroscience

Automatic segmentation of medial temporal lobe subregions in multi-scanner, multi-modality MRI of variable quality

Yue Li, Long Xie, Pulkit Khandelwal, Laura E. M. Wisse, Christopher A. Brown, Karthik Prabhakaran, Matthew Dylan Tisdall, Dawn J. Mechanic-Hamilton, John A. Detre, Sandhitsu R. Das, David A. Wolk, Paul A. Yushkevich

This paper develops a multi-modality MRI segmentation model to improve robustness of medial temporal lobe subregion segmentation in poor-quality images.

Hippocampus · Oct 7, 2025Peer-reviewedBioengineering

Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases

Niyousha Sadeghpour, Sydney Lim, Anika Wuestefeld, Amanda E Denning, Ranjit Ittyerah, Winifred Trotman, Eunice P. Chung, Shokufeh Sadaghiani, Karthik Prabhakaran, Madigan L. Bedard, Daniel T. Ohm, Emilio Artacho‐Pérula, Maria Mercedes Iniguez de Onzono Martin, Mónica Muñoz, Francisco Javier Molina Romero, , Laura E.M. Wisse

The paper develops a segmentation protocol for anterior medial temporal lobe regions and integrates it into an automated approach to improve imaging biomarkers for neurodegenerative diseases.

Hippocampus · Jul 30, 2025Peer-reviewedNeuroscience

Joint ex vivo MRI and histology detect iron-rich cortical gliosis in Tau and TDP-43 proteinopathies

Matthew Dylan Tisdall, Daniel T. Ohm, Rebecca Lobrovich, Sandhitsu R. Das, Gabor Mizsei, Karthik Prabhakaran, Ranjit Ittyerah, Sydney Lim, Corey T. McMillan, David A. Wolk, James C. Gee, John Q. Trojanowski, Edward B. Lee, John A. Detre, Paul A. Yushkevich, , David John Irwin

This study uses joint ex vivo MRI and histology to identify distinct iron-rich gliosis patterns in FTLD-Tau and FTLD-TDP, distinguishing them from other neurodegenerative conditions.

bioRxiv · Apr 14, 2021 · PreprintNeuroscience

3D Mapping of Neurofibrillary Tangle Burden in the Human Medial Temporal Lobe

Paul A. Yushkevich, Mónica Muñoz, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Alex Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, , Ricardo Insausti

This study creates 3D maps of neurofibrillary tangle burden in the human medial temporal lobe using ex vivo MRI and dense histology, revealing variation along the anterior-posterior axis and widespread NFT distribution.

bioRxiv · Jan 15, 2021 · PreprintNeuroscience

Intensity Warping for multisite MRI Harmonization

Julia Wrobel, Melissa L. Martin, Rohit Bakshi, Peter A. Calabresi, M Elliot, David R. Roalf, Ruben C. Gur, Raquel E. Gur, Roland G. Henry, Govind Nair, Jiwon Oh, Nico Papinutto, Daniel Pelletier, Daniel S. Reich, William D. Rooney, , on behalf of the NAIMS Cooperative

This paper develops a method to reduce technical variation in multisite MRI data by aligning intensity distributions across scanners.

NeuroImage · Aug 13, 2020Peer-reviewedNeuroscience

Brain Iron Mediates the Relationship Between Cognition and Neighborhood Socioeconomic Status in Youth

Lauren M. Beard, David R. Roalf, Mark A. Elliott, Karthik Prabhakaran, Tyler M. Moore, Raquel E. Gur, Theodore Daniel Satterthwaite

The paper investigates how brain iron levels in youth relate to cognitive performance and socioeconomic status, hypothesizing that higher iron in basal ganglia regions mediates this relationship.

bioRxiv · Feb 12, 2018 · PreprintNeuroscience