C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1
Margot Van Nerom, Junaid Ahmed, Tamás Lázár, Attila Mészáros, Quentin Galand, Wim De Malsche, Joris Van Lindt, Rita Pancsa, Dominique Maes, Péter Tompa
This study shows that C9orf72-derived arginine-rich dipeptide repeats enhance G3BP1 phase separation, contributing to ALS and FTD pathology.
Proceedings of the National Academy of Sciences · Dec 2, 2024Peer-reviewedMolecular Biology