Dominique Maes

This study shows disease-linked mutations in hnRNPA2B1 accelerate condensate maturation and promote amyloid aggregation by altering phase separation and fibril formation.

This study reports the successful expression and purification of full-length hnRNPA2B1, enabling its use in studying liquid-liquid phase separation and aggregation.

This study shows that C9orf72-derived arginine-rich dipeptide repeats enhance G3BP1 phase separation, contributing to ALS and FTD pathology.

The paper introduces a method to study liquid-liquid phase separation under near-native conditions by using extreme pH to control protein solubility and induce phase separation.