Rui Sang

This study develops a light-responsive lipid nanoparticle platform for VEGFA gene editing to suppress choroidal neovascularisation, showing reduced vascular leakage and structural abnormalities in a rat model.

This paper develops a CRISPR-based biosensing system that uses split-trigger activation to amplify Cas12a activity for ultrasensitive molecular detection.

This paper introduces a CRISPR/Cas tandem biosensing system for ultrasensitive DNA detection without pre-amplification, achieving 1 aM sensitivity and distinguishing cancer mutations in CRC mice.

This paper develops an autocatalytic Cas13a biosensor using circular RNA mediators to enable ultrasensitive RNA detection without preamplification.