Modulating Cas13a trans-cleavage by double strand RNA: Application to the development of an autocatalytic sensor
Fei Deng, Sneha Gulati, Rui Sang, Yi Li, Ewa Magdalena Goldys
This paper develops an autocatalytic Cas13a biosensor using circular RNA mediators to enable ultrasensitive RNA detection without preamplification.
bioRxiv · Mar 5, 2024 · PreprintMolecular Biology