Christian Mayer

The paper identifies developmental trajectories that organize valence-specific circuit assembly in the central amygdala using single-cell profiling and molecular analysis.

The paper shows that the relative abundance of transcription factors SP9 and DLX determines neuronal fate allocation in the developing basal ganglia.

This study shows that disrupted migration of inhibitory neurons leads to persistent functional deficits in cortical networks, linking migratory guidance to circuit integrity.

This paper develops a human brainstem organoid model of H3.3K27M-altered DMG to study GD2 CAR T cell function and identify therapeutic targets.

The paper shows that cortical layering in tetrapods follows conserved developmental principles, with mammals displaying an inverted layer order.

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

The paper investigates how progenitor competence influences GABAergic neuron maturation in mice using single-cell transcriptomics and chromatin profiling, finding that NFIB regulates maturation competence in late-born neurons.

The paper identifies two distinct astrocyte lineages in the mouse neocortex using single-cell RNA sequencing and TrackerSeq, revealing their developmental origins and regulatory mechanisms.

The paper identifies CeA neuron clusters and shows that ghrelin and fasting activate appetitive neurons involved in feeding behavior.

The paper identifies a transient quiescent period in early postnatal development that precedes the emergence of mature cortical dynamics in mice and humans.

The paper uses single-cell RNA-seq to study the development of cortical interneurons, identifying key transcription factors and cell states involved in their diversification.