Synthetic BiologybioRxivPreprint
Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits
Zeyu Mike Lu, Craig P. Barry, Masahiro Tominaga…·Bingyin Peng
The paper develops synthetic genetic circuits in yeast to stabilize metabolic stress from terpene production, showing that coupling essential genes to synthetic pathways improves strain stability.
DOI 10.64898/2026.09.01.748751