Claudia Estelle Vickers

Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits

The paper develops synthetic genetic circuits in yeast to stabilize metabolic stress from terpene production, showing that coupling essential genes to synthetic pathways improves strain stability.

Cyanamide-inducible expression of homing nuclease I-SceI for iterative genome engineering and parallel promoter characterisation in Saccharomyces cerevisiae

The paper develops a cyanamide-inducible system for genome engineering in yeast, enabling selectable marker recycling and promoter characterization.

The integration of tandem gene repeats via a bacterial type-II toxin-antitoxin-mediated gene amplification (ToxAmp) system and stability visualisation in Saccharomyces cerevisiae

The paper develops a bacterial toxin-antitoxin system to manipulate and visualize tandem gene repeat copy numbers in yeast.

Translational fusion of terpene synthases enhances metabolic flux by increasing protein stability

This study shows that fusing terpene synthases increases metabolic flux by boosting enzyme stability and expression, leading to higher nerolidol production.

Synthetic in vivo compartmentalisation improves metabolic flux and modulates the product profile of promiscuous enzymes

This paper demonstrates that synthetic in vivo compartmentalisation of enzymes in yeast significantly increases product titre and modulates product ratios.

Rapid design and prototyping of biocatalytic virus-like particle nanoreactors

The paper presents a vector system for rapidly designing and optimizing biocatalytic nanoreactors using P22 virus-like particles for encapsulating enzymes.

An artificial self-assembling nanocompartment for organising metabolic pathways in yeast

The paper demonstrates an artificial nanocompartment in yeast that enhances metabolic pathway efficiency by stabilizing enzymes and reducing toxicity.

Rational design of novel fluorescent enzyme biosensors for direct detection of strigolactones

The paper develops genetically encoded fluorescent biosensors for detecting strigolactones using plant receptors, showing specific fluorescence changes in response to strigolactones and their analogs.