Evolutionary stabilisation of stressful metabolism via integrated biocomputing and essential-gene metabolic locking circuits
Zeyu Mike Lu, Craig P. Barry, Masahiro Tominaga, Anh Phan, Ali Jahanian, Thomas Collier, Nicholas A. Wendrick, Samuel Evans, Liam McDonnell, Gabriele A. Netzel, Tim McCubbin, Shana Sunny Jacob, Patrick A. da Roza, Xin Xu, Chengqiang Wang, , Bingyin Peng
The paper develops synthetic genetic circuits in yeast to stabilize metabolic stress from terpene production, showing that coupling essential genes to synthetic pathways improves strain stability.
bioRxiv · Oct 9, 2026 · PreprintSynthetic Biology