Wayne Ngo

This study demonstrates that in vivo delivery of genome editing enzymes can be amplified through cell-to-cell transfer, significantly increasing editing efficiency in mice.

This paper develops a virus-like particle-based system for CRISPR gene editing and screening in primary human myeloid cells, identifying TNFAIP3 as a key regulator of inflammatory polarization.

This paper demonstrates T cells can deliver genome editing machinery to target cells via programmable intercellular interactions.

This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.

The paper uses spatiotemporal photocatalytic proximity labeling to track dynamic EGFR interactomes both extracellularly and intracellularly upon EGF activation.

This study compares electroporation and packaged RNP delivery for genome editing, finding that packaged delivery is significantly more efficient and faster.

This study engineers a minimal EDV for genome editing by removing viral components, showing improved efficiency and reduced size.