Gerhard Schenk

TreeGazer selects informative protein sequences using phylogenetic structure and Bayesian optimization, outperforming alternative strategies in simulated campaigns and low-data settings.

The paper identifies and characterizes PDI family members in sorghum to explore their domain architecture, structure, and functionality, highlighting structural differences from human PDIs.

This study shows that fusing terpene synthases increases metabolic flux by boosting enzyme stability and expression, leading to higher nerolidol production.

This paper demonstrates that synthetic in vivo compartmentalisation of enzymes in yeast significantly increases product titre and modulates product ratios.

The paper introduces GRASP, a method for ancestral sequence reconstruction that handles large datasets and indels, demonstrating its ability to generate biologically active enzyme ancestors.