Author
Commonwealth Scientific and Industrial Research OrganisationORCID 0000-0002-0072-2885Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Li Chen Cheah, Lian Liu, Terra Stark, Manuel R. Plan, Bingyin Peng, Zeyu Mike Lu, Gerhard Schenk, Frank Sainsbury, Claudia Estelle Vickers
This study shows that fusing terpene synthases increases metabolic flux by boosting enzyme stability and expression, leading to higher nerolidol production.
Metabolic Engineering · Mar 28, 2023Peer-reviewedSynthetic Biology
Li Chen Cheah, Lian Liu, Manuel R. Plan, Bingyin Peng, Zeyu Mike Lu, Gerhard Schenk, Claudia Estelle Vickers, Frank Sainsbury
This paper demonstrates that synthetic in vivo compartmentalisation of enzymes in yeast significantly increases product titre and modulates product ratios.
bioRxiv · Nov 24, 2022 · PreprintSynthetic Biology
Lachlan S. R. Adamson, Nuren Tasneem, Michael P. Andreas, William Close, Eric N. Jenner, Taylor N. Szyszka, Reginald Young, Li Chen Cheah, Alexander R. Norman, Hugo MacDermott-Opeskin, Megan L. O’Mara, Frank Sainsbury, Tobias W. Giessen, Yu Heng Lau
This study investigates how pore structure affects stability and molecular flux in engineered protein cages through design, structural analysis, and simulations.
Science Advances · Feb 4, 2022Peer-reviewedSynthetic Biology
Li Chen Cheah, Terra Stark, Lachlan S. R. Adamson, Rufika Shari Abidin, Yu Heng Lau, Frank Sainsbury, Claudia Estelle Vickers
The paper demonstrates an artificial nanocompartment in yeast that enhances metabolic pathway efficiency by stabilizing enzymes and reducing toxicity.
ACS Synthetic Biology · Sep 30, 2021Peer-reviewedSynthetic Biology