Frank Sainsbury

This paper demonstrates the use of an asparaginyl endopeptidase ligase to efficiently and selectively functionalize P22 virus-like particles with therapeutic receptor targeting domains.

This paper demonstrates the use of bacteriophage P22 virus-like particles as nanoscale protein scaffolds for plant synthetic biology, showing their ability to assemble, encapsulate, and display proteins in Nicotiana benthamiana.

The paper determines the capsid structure of Atkinsonella hypoxylon virus using cryo-EM and identifies conserved and divergent features among partitiviruses.

This study evaluates a bacteriophage P22 VLP system for encapsulating bioactive peptides in E. coli, showing it aids purification but does not significantly improve peptide yields.

This study shows that fusing terpene synthases increases metabolic flux by boosting enzyme stability and expression, leading to higher nerolidol production.

This paper demonstrates that synthetic in vivo compartmentalisation of enzymes in yeast significantly increases product titre and modulates product ratios.

The paper presents a vector system for rapidly designing and optimizing biocatalytic nanoreactors using P22 virus-like particles for encapsulating enzymes.

This study investigates how pore structure affects stability and molecular flux in engineered protein cages through design, structural analysis, and simulations.

The paper demonstrates an artificial nanocompartment in yeast that enhances metabolic pathway efficiency by stabilizing enzymes and reducing toxicity.