Michael Z. Leonard

This study shows that repeated cocaine exposure reorganizes striatal neural activity patterns along the ventral-dorsal axis in mice, leading to distinct changes in neuronal responses.

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.

This study shows that gut microbiome depletion increases cocaine-seeking behavior in rats, which can be reversed by replenishing short-chain fatty acids.