Claudia Montufar

CRISPR-based neuromorphic computing for solving regression and classification

This paper develops a CRISPR-based neuromorphic computing system using dCas9 and guide RNAs to perform classification and regression tasks, showing invariance in decision boundaries and preserved node thresholds under resource constraints.

Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake

This study shows that inhibiting purine biosynthesis with mizoribine prevents weight gain and improves metabolic health in mice on a high-fat diet by increasing thermogenesis and reducing food intake.