Lianyong Han

The paper evaluates six alveolar macrophage models to identify those best representing in vivo AMs for assessing nanomaterial toxicity, finding AMs GTR and BM-AMs most suitable.

The paper shows that alveolar macrophages recruit neutrophils to sites of nanoparticle deposition in the lung through motility, phagocytosis, and cytokine release.

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

This study shows that TiO2 nanotubes and MWCNTs induce different cancer-related changes in vitro, with TiO2 nanotubes disrupting microtubules and inducing binucleated cells, while MWCNTs activate the STING pathway.