Ruobo Zhou

FLEXTAG improves super-resolution imaging by enabling long-term, multi-color, low-bleaching labeling of subcellular structures in live and fixed cells.

This paper shows the neuronal membrane-associated periodic skeleton (MPS) gates all major endocytic pathways and is remodeled through a signaling-driven feedback loop, impacting neuronal health and Alzheimer's disease.

This paper introduces tools for controlling and visualizing ER-PM contact sites in living cells, showing they can adjust contact size and density independently.

This paper introduces a chemically inducible RTK system that minimizes basal activation and enables precise control over ERK-dependent cellular processes.

The paper defines the minimal sequence requirements of RNA polymerase II CTD across transcriptional stages using structural analysis and synthetic constructs, revealing a 'zipper' model for PIC assembly and transcription progression.

CLaSSiNet classifies nanoscale membrane skeleton networks with high resolution, revealing cell-type-specific organizational patterns and mechanical coupling principles.

This study investigates how histone chaperone Nap1 and acetylation of histone H3/H4 tails regulate phase-separation of chromatin arrays through dynamic DNA-histone interactions.

The paper identifies and validates MPS-interacting proteins in neurons, showing their periodic distribution and functional roles in axon interactions and diameter regulation.

The paper investigates the prevalence of the actin-spectrin-based membrane skeleton (MPS) across neuronal types and species, finding it widespread in axons and some glial processes but absent in presynaptic boutons.