Jiang He

The paper analyzes the spatial molecular architecture of melanoma tumors under different immunotherapy regimens and identifies biomarkers predicting response to treatment.

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

This study identifies how the cortex encodes body schema through action-specific neural ensembles and reference frames in mice.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

The paper compares MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing in mouse liver and kidney, finding MERFISH provides comparable results and robust cell type identification without needing integration with scRNA-seq atlases.

This study compares cellular organization and interactions in human and mouse cortex using single-cell transcriptome imaging, finding conserved laminar organization but divergent cell-cell interactions in humans.

The paper investigates the prevalence of the actin-spectrin-based membrane skeleton (MPS) across neuronal types and species, finding it widespread in axons and some glial processes but absent in presynaptic boutons.