Irnov Irnov

This paper investigates the spatiotemporal regulation of Sae and Agr systems in Staphylococcus aureus during kidney abscess formation, finding Sae activity is heterogeneous and required for abscess progression.

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

This study identifies bacterial enzymes that modify peptidoglycan fragments from Borrelia burgdorferi, showing they are poor immune stimulators and that host enzymes like PGLYRP2 are less active in joint fluids, contributing to persistent arthritis.