Author

Chang-Run Guo

China Pharmaceutical UniversityORCID 0009-0004-2348-3591Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Dong-Ping Wang· 2 shared Michael X. ZhuiD· 2 shared Xing ZhouiD· 2 shared Ye Yu· 2 shared Yuan Gao· 2 shared Ai-Xin Zhang· 1 shared Bei-Bei Ding· 1 shared Bin CuiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Dong-Ping Wang

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3 papers

Recent·Most cited

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels

Dong-Ping Wang, Wanbiao Chen, Xiao-Na Yang, Meng-Yang Sun, Ai-Xin Zhang, Yuan Gao, Xi Chen, Bin Cui, Xing Zhou, Yu Gao, Bei-Bei Ding, Yu Tian, Michael X. Zhu, Changzhu Li, Chang-Run Guo, , Ye Yu

The paper reports cryo-EM structures of human P2X2/3 heterotrimers in different functional states, revealing asymmetric ligand recognition and allosteric coupling mechanisms.

bioRxiv · Apr 6, 2026 · PreprintBiophysics

Cryo-EM reveals the structural basis of subtype-specific, noncompetitive inhibition of the human P2X3 receptor

Zhixuan Zhao, Dong-Ping Wang, Xin Zhang, Yuan Gao, Hexin Xu, Teng Xu, Shen Cheng, Jirui Chen, Jinru Zhang, Ye Yu, Chang-Run Guo, Motoyuki Hattori

The paper reports the cryo-EM structure of the human P2X3 receptor complexed with sivopixant, revealing subtype-specific allosteric inhibition mechanisms and structural basis for improved selectivity.

bioRxiv · Jan 3, 2026 · PreprintBiophysics

Endogenously expressed P2X5 includes a proportion of isoforms or transcript variants sensitive to extracellular ATP

Xiaona Yang, Dongping Wang, Chen‐Hui Shen, Xijing Chen, Hui Yang, Xing Zhou, Chang-Run Guo, Yun Tian, Michael X. Zhu, Yu Ye

The study identifies ATP-sensitive P2X5 isoforms and transcript variants in multiple species, challenging the assumption of their ATP-insensitivity.

bioRxiv · Jan 10, 2025 · PreprintPhysiology