Author

Alicia Calvo‐Villamañán

Centro Nacional de BiotecnologíaORCID 0000-0001-7033-2834Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:clustering· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Álvaro San MillániD· 4 shared Jorge Sastre-DomíngueziD· 3 shared Coloma CostasiD· 2 shared Didier MazeliD· 2 shared Susana Quesada· 2 shared Aida Alonso-del ValleiD· 1 shared Alfonso Santos-LópeziD· 1 shared Álvaro Barrera-MartíniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

Álvaro San MillánORCID

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4 papers

Recent·Most cited

MicrobiologyNature MicrobiologyPeer-reviewedMar 13, 2026

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Jorge Sastre-Domínguez, Paloma Rodera-Fernandez, Javier DelaFuente…·Álvaro San Millán

This study shows plasmids contribute to antimicrobial resistance by promoting gene inactivation via insertion sequences in Klebsiella pneumoniae.

8 citationstop 1%

E. coliwhole-genome sequencing

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MicrobiologybioRxivPreprintFeb 25, 2026

Coupling metabolic enhancement to plasmid spread enables programmable antimicrobial control

Pedro Dorado‐Morales, Alicia Calvo‐Villamañán, Bianca Audrain…·Didier Mazel

This paper develops conjugative plasmids that block antibiotic resistance plasmid spread by combining metabolic enhancement and plasmid spread mechanisms in microbial communities.

1 citation

experimental assayhost-pathogen & immune response

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MicrobiologybioRxivPreprintJan 23, 2025

Dissecting pOXA-48 fitness effects in clinical enterobacteria using plasmid-wide CRISPRi screens

Alicia Calvo‐Villamañán, Jorge Sastre-Domínguez, Álvaro Barrera-Martín…·Álvaro San Millán

This study uses CRISPRi screens to analyze fitness effects of the pOXA-48 plasmid in clinical enterobacteria, identifying key genes and mechanisms affecting plasmid stability and transmission.

6 citations

humangenetic perturbation / CRISPR

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MicrobiologyNature CommunicationsPeer-reviewedDec 30, 2024

Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria

Laura Toribio-Celestino, Alicia Calvo‐Villamañán, Cristina Herencias…·Álvaro San Millán

The paper investigates plasmid-chromosome transcriptional interactions in multidrug-resistant bacteria, finding that a plasmid-encoded regulator drives chromosomal operon overexpression, enhancing bacterial fitness and carbapenem resistance dissemination.

20 citations

bacteria (other)bulk RNA-seq

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