Author

Hermann Josef Pavenstädt

University Hospital MünsterORCID 0000-0001-8717-7770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:CRISPR screen· 2 Research Focus:variant calling· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anja Stegemann· 2 shared Birte SeegeriD· 2 shared Boris V. SkryabiniD· 2 shared Helena Kaiser· 2 shared Leonid Gubar· 2 shared Timofey S. RozhdestvenskyiD· 2 shared Barbara Heitplatz· 1 shared Birte Hüchtmann· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Anja Stegemann

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Molecular BiologyiSciencePeer-reviewedOct 21, 2025

CRISPR-Cas9 HDR Optimization: RAD52, Denatured and 5'-Modified DNA Templates in Knock-In Mice Generation

Boris V. Skryabin, Daniela Anne Braun, Helena Kaiser…·Timofey S. Rozhdestvensky

This study identifies strategies to improve CRISPR-Cas9 HDR efficiency in generating conditional knockout mice by optimizing DNA templates and using RAD52 protein.

2 citations

mouseCRISPR screen

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ImmunologybioRxivPreprintApr 2, 2024

Microvascular immunity is organ-specific and concealed in peripheral blood

Rebecca Rixen, Paula Schütz, Carolin Walter…·Konrad Buscher

The paper analyzes microvascular immune cells in mouse organs and compares them to peripheral blood, finding organ-specific immune responses that are not detectable in blood or tissue samples.

DOI 10.1101/2024.04.02.584356

mousescRNA-seq

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GeneticsScience AdvancesPeer-reviewedFeb 12, 2020

Pervasive head-to-tail insertions of DNA templates mask desired CRISPR/Cas9-mediated genome editing events

Boris V. Skryabin, Delf-Magnus Kummerfeld, Leonid Gubar…·Timofey S. Rozhdestvensky

The paper identifies head-to-tail DNA template insertions in CRISPR/Cas9 editing and highlights the failure of PCR to detect them, advocating for comprehensive analysis.

89 citationstop 3%

mouseCRISPR screen

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