Boris V. Skryabin

The paper shows that promoting soluble FLT1 over full-length FLT1 enhances postischemic angiogenesis by modulating gene isoform expression through APA.

This study identifies strategies to improve CRISPR-Cas9 HDR efficiency in generating conditional knockout mice by optimizing DNA templates and using RAD52 protein.

This study investigates the effects of the Scn5a-M1875T mutation in mice, showing increased early sodium current and potential implications for atrial fibrillation treatment.

This study identifies a circular RNA, circAβ-a, that translates into Aβ175, which is processed into Aβ peptides, revealing an alternative pathway for Aβ biogenesis in Alzheimer's disease.

The paper identifies head-to-tail DNA template insertions in CRISPR/Cas9 editing and highlights the failure of PCR to detect them, advocating for comprehensive analysis.

The paper uses DNA barcoding to show that homologous recombination, specifically SDSA and DSBR, predominantly processes injected transgenes in mouse zygotes, with over 80% of copies undergoing recombination.