P. Andrew Karplus

This study develops a highly reactive and stable tetrazine amino acid for site-specific protein labeling, demonstrating improved encoding and ligation efficiency.

This paper introduces an in-cell method to evaluate E3 ligases for targeted protein degradation by conjugating neo-substrates via click chemistry.

The paper develops a system to autonomously produce phosphorylated proteins in E. coli, demonstrating that non-hydrolyzable phosphoserine mimics phosphoserine function in three biological contexts.