Systems BiologyeLifePeer-reviewed
Five-layer systems analysis of Leishmania stage differentiation reveals an essential role for protein degradation in parasite development
Pascale Pescher, Thibaut Douché, Quentin Giai Gianetto…·Gerald Frank Späth
The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.
DOI 10.7554/elife.111115