Karen Druart

This study targets the Sec61 translocon to suppress pathogenic light-chain production in AL amyloidosis, showing that mycolactone and synthetic inhibitors like A317 reduce LC secretion while highlighting the need for client selectivity.

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

The paper describes a method to simultaneously extract high-quality RNA and proteins from the same mosquito samples, enabling both RNA-Seq and LC-MS proteomic analyses.

MSclassifR is an R package that improves mass spectra classification using machine learning, achieving high accuracy on real datasets and outperforming commercial software.

InDeep predicts functional binding sites in proteins for drug design on PPIs, outperforming existing tools on both PPI and conventional targets.