Quentin Giai Gianetto

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

This study shows SARS-CoV-2 ORF9b uses TOMM70 to avoid proteasomal degradation, reduces inflammation, and is not essential for viral replication or lung pathology.

The paper introduces diagFDR, a framework to improve FDR reporting in proteomics by assessing scope, calibration, and stability, and provides tools for verification.

This study identifies L. pneumophila's LpDot1 protein as a bacterial effector that modifies SFPQ, disrupting paraspeckle organization and host splicing, leading to alternative splice variants of infection-related genes.

ProteoBench provides a centralized platform for comparing proteomics data analysis workflows, enabling benchmarking and community collaboration.

This study investigates the structural and functional organization of the de novo purine nucleotide biosynthetic pathway enzymes in Pseudomonas aeruginosa, revealing a metabolon-like complex with potential antibiotic implications.

This study identifies plasma protein biomarkers for early detection of gastric preneoplasia and cancer using proteomics and validation in a cohort, showing high classification performance.

This study identifies nitrate-induced intracytoplasmic membranes in Mycobacterium tuberculosis that help dampen inflammation during infection.

This study identifies ATG16L1's role in IAV-induced PI4P production at the ER, facilitating vRNP egress by coordinating RAB11A and PI4P-enriched membranes.

MSclassifR is an R package that improves mass spectra classification using machine learning, achieving high accuracy on real datasets and outperforming commercial software.

The paper presents a dual proteomic analysis of Yersinia pestis and human immune cells during blood infection, revealing pathogenic signatures and pathway reshaping.

The paper identifies phosphorylation sites in response to DNA breaks in Trypanosoma brucei and finds a specific RPA-1 phosphorylation event required for resection at a subtelomeric locus.

Estimating what fraction of missing proteomics values are missing completely at random lets MCAR- and MNAR-specific imputers be combined; on simulations this beats standard imputation.