Author

Jennifer A. Lo

Broad InstituteORCID 0000-0002-9520-6874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Xiao WangiD· 3 shared Xin SuiiD· 3 shared Connie Kangni WangiD· 2 shared Haowen ZhouiD· 2 shared Hongyu CheniD· 2 shared Hu ZengiD· 2 shared Jia Liu BiD· 2 shared Jiahao HuangiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Xiao WangORCID

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3 papers

Recent·Most cited

Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks

Xin Sui, Jennifer A. Lo, Shuchen Luo, Yichun He, Zefang Tang, Zuwan Lin, Dániel L. Barabási, Yiming Zhou, Wendy Xueyi Wang, Jia Liu B, Xiao Wang

This paper develops Deep-STARmap and Deep-RIBOmap for 3D spatial transcriptomics and translatomics in thick tissue blocks, enabling analysis of gene expression and immune interactions in human skin cancer.

Nature Methods · Nov 24, 2025Peer-reviewedGenomics

Spatially Resolved Single-cell Translatomics at Molecular Resolution

Hu Zeng, Jiahao Huang, Jingyi Ren, Connie Kangni Wang, Zefang Tang, Haowen Zhou, Yiming Zhou, Hailing Shi, Abhishek J. Aditham, Xin Sui, Hongyu Chen, Jennifer A. Lo, Xiao Wang

The paper introduces RIBOmap, a 3D in situ method to profile mRNA translation at single-cell and spatial resolutions, revealing translation dependencies on cell cycle and subcellular localization in brain tissue.

Science · Jun 29, 2023Peer-reviewedGenomics

Spatiotemporally resolved transcriptomics reveals subcellular RNA kinetic landscape

Jingyi Ren, Haowen Zhou, Hu Zeng, Connie Kangni Wang, Jiahao Huang, Xiaojie Qiu, Xin Sui, Qiang Li, Xunwei Wu, Zuwan Lin, Jennifer A. Lo, Kamal Maher, Yichun He, Xin Tang, Judson Lam, , Xiao Wang

This paper introduces TEMPOmap, a method to profile subcellular RNA kinetics in single cells, revealing kinetic gene clusters with distinct functional roles.

Nature Methods · Apr 10, 2023Peer-reviewedGenomics