ImmunologybioRxivPreprint
Ligand-responsive groove remodelling in human and macaque CD1d reveals a conserved MHC-like gating mechanism
Daniel J. Burns, Alex Look, Steven Turner…·Salah Mansour
This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.
DOI 10.64898/2025.12.23.695970