Author

Alex Look

National Institute for Health and Care ResearchORCID 0000-0002-8492-0888Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1 Assay:structural biology· 1

Frequent Co-Authors

Andrew WhiteiD· 2 shared Kinga Niedobecka· 2 shared Paul T. ElkingtoniD· 2 shared Rita Szoke‐KovacsiD· 2 shared Salah MansouriD· 2 shared Alasdair J. LeslieiD· 1 shared Ali RoghanianiD· 1 shared Andrés F. VallejoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Andrew WhiteORCID

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2 papers

Recent·Most cited

ImmunologybioRxivJun 23, 2026

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

Matthew Milton, Sahar H. Farag, Diana J. Garay‐Baquero…·Salah Mansour

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

DOI 10.7554/elife.110341

humanbulk RNA-seq

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ImmunologybioRxivPreprintDec 25, 2025

Ligand-responsive groove remodelling in human and macaque CD1d reveals a conserved MHC-like gating mechanism

Daniel J. Burns, Alex Look, Steven Turner…·Salah Mansour

This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.

DOI 10.64898/2025.12.23.695970

humannon-human primate

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