Andrew White

Increased EV yield and bioactivity of matrix-bound nanovesicles compared to conditioned culture medium-derived extracellular vesicles

This study compares EV yields and bioactivity between liquid-EVs and MBVs from MSCs, finding MBVs have significantly higher yields and are more effective in wound repair.

Human CD1c-autoreactive T cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes

This study shows CD1c-autoreactive T-cells recognize Mtb-infected APCs, exhibit cytotoxicity, and reduce Mtb burden through CD1c-dependent mechanisms.

Ligand-responsive groove remodelling in human and macaque CD1d reveals a conserved MHC-like gating mechanism

This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.

Fleming: An AI Agent for Antibiotic Discovery in Mycobacterium Tuberculosis

Fleming is an AI agent that identifies lead compounds for Mycobacterium tuberculosis by combining discriminative and generative models, achieving higher discrimination and hit rates than alternative approaches.

Mtb specific HLA-E restricted T cells are induced during Mtb infection but not after BCG administration in non-human primates and humans