Javier Fernández-Chamorro

The paper uses isoform-specific single-cell Perturb-Seq to show that alternative promoters drive distinct transcriptional programs and affect drug response in breast cancer.

This study shows that alternative splicing modulates protein interfaces to control localization by altering exon structure and charge distribution.

This paper identifies a novel dimerization module in Gemin5 that mediates protein interactions and translation control through structural and functional analysis.

The paper identifies Rab1b and ARF5 as novel RNA-binding proteins involved in IRES-driven RNA localization and translation regulation.