Helaine Graziele Santos Vieira

This paper introduces scDaisyChain to analyze X chromosome inactivation escape and skew in immune cells, revealing lineage-specific effects on gene dosage and variant exposure in healthy and autoimmune disease contexts.

The paper uses isoform-specific single-cell Perturb-Seq to show that alternative promoters drive distinct transcriptional programs and affect drug response in breast cancer.

This study shows that alternative splicing modulates protein interfaces to control localization by altering exon structure and charge distribution.

The paper introduces DTI, a new RNA integrity metric based on nanopore sequencing, and the INDEGRA package to correct biases and enable accurate transcriptome comparisons.

This study investigates the role of RPL3L in ribosome heterogeneity and mitochondrial activity in cardiomyocytes, finding that its depletion increases ribosome-mitochondria interactions and ATP levels.

The paper introduces a method to quantify RNA modifications using nanopore sequencing, revealing novel modification sites and dynamics in yeast under environmental stress.

The paper investigates the subcellular relocalization of TRMT1 and TRMT1L during neuronal activation and identifies their role in RNA modification dynamics and neuronal plasticity.