Robert J. Weatheritt

The paper identifies FBXW11 as a negative regulator of radial glial expansion and neuronal maturation in human cerebral organoids through CRISPR screening and functional validation.

This paper introduces scDaisyChain to analyze X chromosome inactivation escape and skew in immune cells, revealing lineage-specific effects on gene dosage and variant exposure in healthy and autoimmune disease contexts.

SWARM improves detection of RNA modifications by reducing false positives and reveals new splicing-related pseudouridylation patterns.

The paper uses isoform-specific single-cell Perturb-Seq to show that alternative promoters drive distinct transcriptional programs and affect drug response in breast cancer.

This study shows that combining FACT and BET inhibition disrupts oncogenic transcription and extends survival in Diffuse Midline Glioma models.

This study shows that alternative splicing modulates protein interfaces to control localization by altering exon structure and charge distribution.

The paper introduces DTI, a new RNA integrity metric based on nanopore sequencing, and the INDEGRA package to correct biases and enable accurate transcriptome comparisons.

The paper presents a long-read RNA sequencing atlas across mammals, revealing conserved transcript complexity and m6A modifications, and their evolutionary roles.

The paper investigates 5hmC and TET enzyme function in non-vertebrate deuterostomes, showing conserved 5mC removal from regulatory regions across species.

This study examines circRNA evolution across primates, finding that expression profiles diverge rapidly between species but some circRNAs show long-term neural conservation.

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.

Whippet efficiently detects and quantifies alternative splicing, revealing extensive transcriptomic complexity and higher prevalence in tumors.