Tim Harvey‐Samuel

Sequence mismatch between gene-drive and target-site flanking regions significantly impairs homing efficiency in Culex quinquefasciatus

This study shows that sequence mismatches between gene-drive and target-site flanking regions reduce homing efficiency in Culex quinquefasciatus by up to 54%.

CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.

This study demonstrates CRISPR-based gene drives in Culex quinquefasciatus, showing biased inheritance of transgenes with modest efficiency.

Small silencing RNAs expressed from W-linked retrocopies of Masculinizer target the male-determining gene PxyMasc during female sex determination in the Diamondback moth Plutella xylostella

The paper identifies small silencing RNAs targeting PxyMasc, a male-determining gene in diamondback moth, expressed from W-linked retrocopies on the female-specific chromosome.

Towards CRISPR/Cas9-based gene drive in the diamondback moth Plutella xylostella

This study tests a CRISPR/Cas9 split-drive system in the diamondback moth, showing high somatic editing but limited germline activity.

Engineered expression of the invertebrate-specific scorpion toxin AaHIT reduces adult longevity and female fecundity in the diamondback moth Plutella xylostella

This paper shows that expressing the scorpion toxin AaHIT in diamondback moth reduces adult lifespan and female egg production, demonstrating a non-cell-autonomous genetic pest management approach.