Xuejiao Xu

This study evaluates Cas9 fusion proteins in Drosophila to enhance homing gene drive performance by improving HDR and reducing resistance.

The paper develops a confined gene drive system called TARE in Anopheles stephensi to modify mosquito populations, showing it can spread but faces challenges from fitness costs and resistance.

This study shows that knocking out two polyphenol oxidase genes in Nicotiana benthamiana improves recombinant protein purification by reducing aggregation and increasing yields.

This study evaluates CRISPR-based homing gene drives targeting female fertility genes in Drosophila to suppress population growth, finding varying efficiency and fitness costs across targets.

This paper introduces a two-target gene drive design that improves suppression efficiency by combining homing and fitness cost elements, showing success in Drosophila but highlighting remaining challenges.

This study evaluates the efficiency and resistance allele formation of two CRISPR/Cas9-based gene drives in Aedes aegypti, finding one drive achieves super-Mendelian inheritance rates.

This study combines female-lethal alleles with homing gene drive to improve population suppression efficiency while maintaining self-limiting properties in mosquitoes.

This study develops a gene drive in Anopheles stephensi to suppress malaria populations by targeting the doublesex gene, showing partial success with resistance and improved conversion when combined with a vasa-Cas9 line.

This paper describes a homing gene drive targeting the hairy gene in insects, which spreads to high frequency in cage populations but generates functional resistance alleles despite using multiple gRNAs.

The paper identifies new germline Cas9 promoters in Drosophila that improve drive conversion efficiency while reducing embryo resistance and somatic expression.

This paper evaluates distant-site rescue elements for CRISPR toxin-antidote gene drives and finds they fail for both haplolethal and haplosufficient target genes.

This paper develops a homing suppression gene drive in Drosophila using multiplexed gRNAs to prevent resistance alleles, achieving high conversion efficiency and moderate population suppression.

This study tests a CRISPR/Cas9 split-drive system in the diamondback moth, showing high somatic editing but limited germline activity.

This paper shows that expressing the scorpion toxin AaHIT in diamondback moth reduces adult lifespan and female egg production, demonstrating a non-cell-autonomous genetic pest management approach.