Targeting cellular senescence alleviates bone marrow aging
Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
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Johns Hopkins UniversityORCID 0000-0001-8799-5140Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
Courtney E. Campagna, Andrew M. Larey, Kanupriya R. Daga…·Ross A. Marklein
This study develops a high-throughput morphological assay to evaluate how MSC-EVs modulate brain pericyte secretory phenotype, showing distinct morphological responses under different manufacturing conditions.
Christopher Cherry, David R. Maestas, Jin Han…·Jennifer H. Elisseeff
The paper creates a single cell atlas of biomaterials response using scRNA-seq and develops a tool to analyze intercellular signaling patterns in the context of biomaterials.