David R. Maestas

Resolving differential vascular graft remodeling using longitudinal multiphoton tracking in a 3D culture platform

This study develops a 3D culture platform to track vascular graft remodeling using multiphoton imaging, showing differential responses to TGF-β isoforms and agreement with long-term explant data.

γδ17 T cell-stromal networks modulate matrix composition and vascularity in foreign body response

This study shows that γδ17 T cells influence fibrosis by altering ECM composition and vascularity through interactions with stromal cells.

Tissue Injury and Biomaterial Treatment Modulate Tumor Growth and Response to Immunotherapy

This study shows that tissue injury accelerates tumor growth and reduces response to immunotherapy in mice, but biomaterials that enhance wound healing can improve outcomes and ICB response.

Immune checkpoint inhibitors amplify type 2 immune mediated repair bypro-regenerative scaffolds

This study shows immune checkpoint inhibitors enhance type 2 immunity and regeneration in ECM-treated wounds by promoting Treg/TH2 plasticity and pro-regenerative macrophages.

Regulatory T cells clonally expand and contribute to stromal cell function in fibrotic response to synthetic implants

The paper identifies Treg clonal expansion and immunosuppressive functions in fibrosis induced by synthetic implants, showing their role in modulating stromal cell behavior.

Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant

This study shows that gut microbiota dysbiosis from enteric infection increases immune cell recruitment to a distant biomaterial implant, affecting the foreign body response.

Intercellular signaling dynamics from a single cell atlas of the biomaterials response

The paper creates a single cell atlas of biomaterials response using scRNA-seq and develops a tool to analyze intercellular signaling patterns in the context of biomaterials.