Targeting cellular senescence alleviates bone marrow aging
Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
Author
University of Florida HealthORCID 0000-0003-4730-6763Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Bowen Yan, Jin Han, Yang Yang…·Olga A. Guryanova
This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.
Hissah Alatawi, Nair Hariprasad Haritha, Lingbao Ai…·Satya Narayan
This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.
Bowen Yan, Qingchen Yuan, Prabhjot Kaur…·Olga A. Guryanova
This study shows that Dnmt3a mutations in clonal hematopoiesis drive metabolic diseases like obesity and diabetes in mice, especially under high-fat diet.