Olga A. Guryanova

This study shows that clearing senescent cells with 753b improves bone marrow aging by restoring HSC function and niche balance.

This paper identifies DH20931 as a first-in-class agonist of CerS2 that induces ER stress and apoptosis in TNBC cells, showing preclinical efficacy.

This study shows that Dnmt3a mutations in clonal hematopoiesis drive metabolic diseases like obesity and diabetes in mice, especially under high-fat diet.

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

This study shows midbrain dopamine neurons modulate splenic immunity via a brain-to-body circuit involving the DVC and celiac ganglion, reducing spleen weight and naive CD4+ T-cell populations.