Author

Patrick C. Freitag

University of ZurichORCID 0000-0001-8803-6048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Andreas PlückthuniD· 3 shared Fabian Weiss· 2 shared Jonas KolibiusiD· 2 shared Anja KipariD· 1 shared Felix GantenbeiniD· 1 shared Karin Jutta MetzneriD· 1 shared Sarah KlinnertiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

Andreas PlückthunORCID

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3 papers

Recent·Most cited

BiochemistryMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedSep 1, 2025

Genome-replicating HC-AdV, a novel high-capacity adenoviral vector class featuring enhanced in situ payload expression

Jonas Kolibius, Fabian Weiss, Patrick C. Freitag, Andreas Plückthun

This paper develops a genome-replicating high-capacity adenoviral vector that enhances transgene expression without causing host cell death.

5 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryMolecular Therapy OncologyPeer-reviewedApr 14, 2025

Dendritic cell targeting in lymph nodes with engineered modular adapters improves HAdV5 and HC-HAdV5 tumor vaccination by co-secretion of IL-2v and IL-21

Fabian Weiss, Jonas Kolibius, Patrick C. Freitag…·Andreas Plückthun

This paper develops a modular adapter system to target dendritic cells with adenoviral vectors, enhancing tumor vaccination by improving DC transduction and co-delivering cytokines.

3 citations

𝕏 PostBluesky

MicrobiologybioRxivPreprintDec 18, 2023

Targeting HIV-1 with CRISPR/Cas9 delivered by retargeted adenoviruses effectively suppresses viral replication

Sarah Klinnert, Patrick C. Freitag, Andreas Plückthun, Karin Jutta Metzner

This study combines CRISPR/Cas9 with retargeted adenoviruses to suppress HIV-1 replication in primary CD4+ T cells.

1 citation

humangenetic perturbation / CRISPR

𝕏 PostBluesky